Elvis Martis

Experience

US2B, Nantes Université

Postdoctoral Fellow
2023-Till date
  • In-Silico Screening of small molecule hits for protein-protein interfaces.
  • Molecular Docking, Free Energy Calculations, structure-based drug design.
  • Protein Design using state-of-the-art deep learning methods.

Bombay College of Pharmacy

Assistant Professor [ad-hoc]
Mumbai, India
Feb. 2020 – Sept. 2023
  • Subjects Taught: Organic and Medicinal Chemistry
  • Students Co-Supervised for Bachelor's and Master's projects

ChemBio Discovery Inc.

Computational Chemist
Boston, MA, USA (Remotely from India)
Feb. 2019 - Feb. 2020
  • Early-Phase Small molecule Discovery
  • Lead optimisation (structure-based strategies)
  • Molecular dynamics simulations and free energy calculations

Education

Bombay College of Pharmacy [Mumbai University]

Ph.D. (Pharmaceutical Chemistry)
2015-2019 | Mumbai, India
  • Studied the effect of mutations on proteins
  • Developed a method to understand Drug-resistant mutations
  • Molecular Docking, Free Energy Calculations, Essential dynamics of proteins

Bombay College of Pharmacy [Mumbai University]

M.Pharm (Pharmaceutical Chemistry)
2011-2013 | Mumbai, India
  • Developed 3D-QSAR (CORIA) models for acetylcholinesterase
  • Molecular Docking, 3D-QSAR, Virtual Screening, In-vitro Assay

VES College of Pharmacy [Mumbai University]

Bachelor of Pharmacy
2007-2011 | Mumbai, India

Skills

Computational Chemistry
Molecular Dynamics Simulations Structure-based Drug Design Protein Structure Prediction Free Energy Calculations QSAR and 3D-QSAR Protein Design
Software Suits
AMBER-MD: Molecular Dynamics Schrödinger: small molecule discovery suite Osprey: protein design Haddock: protein-protein docking ORCA: Quantum Chemistry package RDKIT: Chemoinformatics ProteinMPNN: de novo protein design Rosetta suite PIPER: protein-protein docking
Programming Languages
Python BASH
Languages
English Hindi Marathi Konkani German (Beginner) French (Beginner)

Recent Publications

Ten quick tips to perform meaningful and reproducible molecular docking calculations
Elvis A. F. Martis, Stéphane Téletchéa
Plos Computational Biology (2025)
Enhanced solubility and oral bioavailability of niclosamide-sulfobutylether-β-cyclodextrin sodium inclusion complexes: An approach to improve its repurposing potential
M Kulkarni, V Shirsat, E Martis , S Vibhute, T Patil, S Kulkarni, E Coutinho
Materials Today Communications 39 109202 (2024)
A-kinase anchoring proteins are enriched in the central pair microtubules of motile cilia in Chlamydomonas reinhardtii
VG Rao, AA Shendge, PP D'Gama, EAF Martis , S Mehta, EC Coutinho
FEBS letters 598 457-476 (2024)
Identification of potential antileishmanial 1, 3-disubstituted-4-hydroxy-6-methylpyridin-2 (1H)-ones, in vitro metabolic stability, cytotoxicity and molecular modeling studies
MR Borkar, EAF Martis , S Nandan, RH Patil, A Shelar, KR Iyer, K Raikuvar, et. al.
Chemico-Biological Interactions 351 109758 (2022)
Design, synthesis and SAR of antitubercular benzylpiperazine ureas
S Satish, R Chitral, A Kori, B Sharma, J Puttur, AA Khan, D Desle, E Martis , et. al.
Molecular Diversity 26 73-96 (2022)

Awards

BiosolveIT Scientific Challenge Finalist
2020-21
Best Research Project at "Avishkar- Inter-University Research Convention 2012"
2012
University Level (Medicine and Pharmacy, Post-Graduate Category)
Best Outgoing Student
2011
Vivekanand Education Society College of Pharmacy
Best Poster Award
2010
3rd Indian Pharmaceutical Association Student's Congress

Fellowships & Grants

Nvidia GPU seeding Grant
2015
Awarded jointly with Prof Dr Evans Coutinho
Modelling Chemical and Biological (Re)activity 4 (MCBR4)
2015
IndoGerman Consortium visiting fellowship (Feb to April 2015)
HeinrichHeine-Universität Düsseldorf, Institut für Pharmazeutische und Medizinische Chemie, Germany
Under Prof Dr Holger Gohlke
BASF SE fellowship
2014-16
For doctoral studies
Government of India, Ministry of Human Resources' scholarship
2011-13
For pursuing Master of Pharmacy

Blogs